Contributing experts: Kristen Quigley, Chief Clinical Operations Officer; Sarah Huntley, Clinical Data Management; Joshua Pellam, Clinical Lead
Hinge Bio is a lean biotech company developing first-in-class therapies for autoimmune and inflammatory diseases. When launching its first-in-human Phase I study, Hinge needed a clinical trial technology partner that could match their pace without the cost, complexity, or long timelines of enterprise EDC vendors.
Previous enterprise EDC experiences made even simple database changes feel burdensome, with vendor-led updates taking weeks or months and adding cost. The team wanted more control over study builds and mid-study updates.
As a small company, Hinge also wanted to consolidate vendors, adopt an easy-to-use EDC, and work with a team that values them. Since multiple systems, logins, and workflows can create unnecessary friction for site teams, Hinge needed an EDC that was easy for sites.
The Solution
The Hinge team implemented Medrio EDC to support its Phase I clinical studies, including a healthy-volunteer dose-escalation study. To simplify vendor management and reduce site burden, they also adopted Medrio ePRO and RTSM, consolidating key workflows under one integrated platform.
Medrio provides the right balance of clinical rigor, usability, support, and cost. The Hinge team can make form and database updates directly, often faster than the internal documentation process required to approve them. Their EDC choice gives them the ability to build, test, and update studies quickly without waiting on vendor-led programming.
With the autonomy to make changes as needed, the Hinge team has control of their study without the risk of hidden costs. When needed, they have access to 24/7 customer support from a responsive, expert team.
Hinge chose Medrio as their partner due to:
- Operational efficiency: Streamline study builds, routine migrations, and mid-study updates without vendor bottlenecks
- Cost transparency: Reduce spend with predictable pricing and no hidden fees for additional changes
- Customer support: Receive support from a responsive team of experts who are ready to help.
The Benefits of Using Medrio
The Hinge team chose Medrio as an easy-to-use, cost-effective solution offering independence and speed. By doing so, they took control of their study build and mid-study updates without delays or upcharges.
Accelerated study timelines
With Medrio EDC, Hinge Bio built the database, tested the database, and completed the full study setup in roughly four weeks. Hinge Bio reused forms and visits from its first study to complete setup in about two weeks of a second Phase I trial. Study builds didn’t require external build support or vendor-led programming, giving Hinge full control over their system.
Features & Support:
- eCRF reuse and templates
- Self-serve database build
- User Acceptance Testing (UAT)
“I’m impressed by the cost, the ease of use, and the speed at which you can get the database up and running.” —Sarah Huntley, Clinical Data Management at Hinge Bio
Predictable costs and flexible terms
Compared to enterprise vendors, Medrio offered significantly lower costs and more startup-friendly terms—including quarterly payment options. The team avoided the fees and delays associated with vendor-managed database changes, keeping spend predictable throughout the study.
Features & Support:
- No change-order fees for database updates
- Flexible payment terms
- Transparent, competitive pricing
“Our Medrio account rep was great. She was super responsive and got back to us really quickly with answers to questions. It was just a very different experience than working with [an enterprise vendor].”—Kristen Quigley, Chief Clinical Operations Officer at Hinge Bio
Streamlined site and team experience
By consolidating EDC, ePRO, and RTSM under one vendor, Hinge Bio reduced the number of systems sites had to navigate. Fewer logins, integrated workflows, and an intuitive interface helped clinical sites operate efficiently—an important factor for a startup focused on building strong site relationships.
Features & Solutions:
- Integrated EDC, ePRO, and RTSM platform
- Single sign-on access
- Intuitive, site-friendly interface – 24/7 global technical support
“It is a really phenomenal platform. The sites are able to use it very efficiently, which is the most important thing for me.”—Joshua Pellam, Clinical Lead at Hinge Bio
Running a Nimble and Cost-Effective Phase I Study
Hinge Bio chose Medrio because it gave their lean clinical team the right balance of control, usability, support, and cost. Instead of relying on a large enterprise vendor for every database change, the team could build, adapt, and manage studies themselves. When they needed it, they could easily get responsive, expert support.
Medrio also helped Hinge Bio consolidate key study workflows under one vendor. With EDC, ePRO, and RTSM available through an integrated platform, Hinge Bio could streamline vendor management, simplify site access, and keep studies moving without unnecessary complexity.
To learn more about what Medrio can do for you, connect with our experts.
