Clinical Trial Management Built
for Speed and Scale
Run your clinical trials efficiently with full audit-readiness. Medrio CTMS, powered by Engility®, is a single system of record for study planning, site management, and trial monitoring.
You shouldn’t have to decide between speed
and compliance.
not months
Hit the ground running from day one with a pre-configured clinical trial management system built for agility.
Demonstrate GCP compliance with complete, audit-ready records that hold up from first patient in through study close.
Safeguard your timelines by tracking enrollment, milestones, and quality metrics in real time.
Centralize your operations and stay audit-ready
Fragmented data creates bottlenecks and creates risks your team doesn’t need. Medrio CTMS consolidates site, investigator, study, and monitoring data into one structured system of record. A platform that connects directly to Medrio EDC and eTMF, automatically linking operational data to study documentation. .
Your team gains a documented operational foundation that holds up under scrutiny and drives the study forward.
Scale your trials
without the enterprise complexity
Scale without the implementation burden or rigid constraints of legacy systems that slow down emerging sponsors and CROs.
Medrio CTMS gives you the features that matter, like automated monitoring, visit reports, and milestone tracking.
Trusted by clinical teams
Recognized by industry peers as one of the best partners.
“What truly enhances the experience is Medrio’s responsive and knowledgeable support team; they’re quick to assist and genuinely invested in user success.”
From planning to closeout and beyond
One platform to run leaner, faster, audit-ready clinical trials.
Improve data quality, engagement, and retention with a patient-centric solution.
Optimize supply chain with self-service randomization and inventory management.
Unify site monitoring, compliance, and clinical operations in one audit-ready workspace.
Automate document filing and compliance tracking to stay audit-ready from day one.
Meet the highest compliance standards
Ready to see Medrio?
Book a live, personalized demo to see for yourself why
clinical trial leaders trust Medrio.
Frequently asked Medrio CTMS questions
How do I evaluate & choose the best CTMS software vendor?
The best clinical trial management system vendors prioritize agile efficiency over enterprise complexity. For small to midsize biopharma or CROs and startups, look for CTMS software that offers a model designed to deliver speed and control. Rapid implementation, guaranteed compliance, and centralized data should be balanced with high-touch expert services to bridge resource gaps.
What is the difference between a CTMS and EDC system?
While an electronic data capture (EDC) system captures patient data, a clinical trial management system (CTMS) refers to managing operational data like enrollment, milestones, and quality metrics. Medrio’s core strength is a unified experience where EDC, ePRO, eConsent, RTSM, and CTMS integrate as one source of truth.
Why is Medrio among the leading CTMS vendors for 2026?
Medrio CTMS stands out against legacy giants like Veeva CTMS, Medidata CTMS, and Oracle CTMS by offering rapid deployment, modern agility, and total autonomy. Our platform is a top Rave CTMS alternative, purpose-built to help fast-growing CROs and medical device companies scale without the rigid complexity of older systems.
How does Medrio CTMS integrate with eSource, EDC and eTMF?
Medrio CTMS eliminates compliance gaps by automatically linking operational data to study documentation. Through a seamless CTMS and EDC integration, subject and visit data captured at the source flow directly into your unified clinical trial management system with no manual reconciliation required. By unifying Medrio EDC, Medrio CTMS, and Medrio eTMF, you create a single source of truth that automates monitoring and filing workflows, allowing for a frictionless transition between study phases.
Is Medrio among the best CTMS solutions for smaller biotech companies & CROs?
Yes, Medrio is the right-sized CTMS partner for scaling companies looking to centralize and automate their trial monitoring. With Medrio CTMS, smaller teams can maintain total operational control, strengthen governance, and feel confident in audit readiness from startup to closeout, without overpaying for unused features.
Does Medrio CTMS ensure compliance with 21 CFR Part 11 and GDPR?
Yes. Medrio CTMS addresses clinical data privacy and audit trail requirements through a foundation of industry regulatory compliance and best practices. Additionally, Medrio CTMS is protected by robust security measures, role-based access controls, and data encryption.
What is a "site-centric" CTMS and does Medrio support it?
Medrio CTMS supports a site-centric approach by reducing the data entry burden through a unified clinical trial management system. Because our CTMS is integrated with Medrio EDC, sites can capture data once at the source, eliminating double data entry that often slows down study coordinators. This focus on ease-of-use allows site users to spend less time on administrative tasks and more time on patient care.
Can Medrio CTMS automate the management of investigator payments & financial tracking?
Yes, Medrio CTMS can introduce automated processes for site payments based on milestones completed in the EDC. This provides financial transparency and eliminates the manual reconciliation errors common in spreadsheet-based tracking.
What is a typical timeline for CTMS implementation & data migration through Medrio?
While most CTMS solutions require months to go live, Medrio CTMS enables teams to launch in a matter of weeks. We provide a frictionless transition for those moving from legacy spreadsheets or systems like Oracle, preserving your historical audit trail throughout the migration.